Function of FXYD Proteins, Regulators of Na, K-ATPase
نویسندگان
چکیده
منابع مشابه
FXYD proteins: new regulators of Na-K-ATPase.
FXYD proteins belong to a family of small-membrane proteins. Recent experimental evidence suggests that at least five of the seven members of this family, FXYD1 (phospholemman), FXYD2 (gamma-subunit of Na-K-ATPase), FXYD3 (Mat-8), FXYD4 (CHIF), and FXYD7, are auxiliary subunits of Na-K-ATPase and regulate Na-K-ATPase activity in a tissue- and isoform-specific way. These results highlight the co...
متن کاملTranscriptional regulators of Na,K-ATPase subunits
The Na,K-ATPase classically serves as an ion pump creating an electrochemical gradient across the plasma membrane that is essential for transepithelial transport, nutrient uptake and membrane potential. In addition, Na,K-ATPase also functions as a receptor, a signal transducer and a cell adhesion molecule. With such diverse roles, it is understandable that the Na,K-ATPase subunits, the catalyti...
متن کاملA functional interaction between CHIF and Na-K-ATPase: implication for regulation by FXYD proteins.
Like the gamma-subunit of Na-K-ATPase, the corticosteroid hormone-induced factor (CHIF) is a member of the FXYD family of one-transmembrane-segment proteins. Both CHIF and two splice variants of gamma, gamma(a) and gamma(b), are expressed in the kidney. Immunolocalization experiments demonstrate mutually exclusive expression of CHIF and gamma in different nephron segments. Specific coimmunoprec...
متن کاملStructural and functional interaction sites between Na,K-ATPase and FXYD proteins.
Several members of the FXYD protein family are tissue-specific regulators of Na,K-ATPase that produce distinct effects on its apparent K(+) and Na(+) affinity. Little is known about the interaction sites between the Na,K-ATPase alpha subunit and FXYD proteins that mediate the efficient association and/or the functional effects of FXYD proteins. In this study, we have analyzed the role of the tr...
متن کاملXYD Proteins : issue - Specific Regulators of the Na , K - ATPase aim Garty and Steven
Work in several laboratories has led to the identification of a family of short single-span transmembrane proteins named after the invariant extracellular motif: FXYD. Four members of this group have been shown to interact with the Na,K-adenosine triphosphatase (ATPase) and alter the pump kinetics. Thus, it is assumed that FXYD proteins are tissuespecific regulatory subunits, which adjust the k...
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ژورنال
عنوان ژورنال: Journal of Bioenergetics and Biomembranes
سال: 2005
ISSN: 0145-479X,1573-6881
DOI: 10.1007/s10863-005-9476-x